Applications of the Dopaminergic System Expressed by Peripheral Blood Lymphocytes in Neuropsychiatric Disorders

Introduction: Dopamine (DA) is essential for the central nervous system (CNS) regulation of neurological, psychological, behavioral, and hormonal processes. Objective: In order to establish viability peripheral blood lymphocytes (PBL) as a molecular tool examining DA dysregulation in neurological diseases, this research sets out current characterization PBL. Methods: This study was carried at Khyber teaching hospital from Jan 2022 April 2022. Twenty-three (23) patients suffering with Parkinson's disease (PD) participated that (average age 56 years, mean disorder length 28 months). Nine these participants received treatment direct dopamine agonist medications, whereas other 14 were drug-naive (levodopa-naive group). Results: Norpramin, noradrenaline uptake blocker, established its efficacy dosages numerous times elevated than blockers uptake, but serotonin inhibitor Prozac inactive. transporter immunoreactivity levels varied significantly across groups, according ANOVA analysis (KW=27, P=0.001). Conclusion: PBL may function biological probe identify transmission disruption neuropsychiatric illnesses track pharmaceutical therapies Keywords: dopamine, dopaminergic system, lymphocytes, disorders